NovaCell鈥敳萘裆缜�檚 Center for Cellular Engineering
Founded in 2018, NovaCell鈥檚 mission is to lead efforts to improve cell and gene therapy products, and the bioprocesses used to make them.
In August 2017, the U.S. Food and Drug Administration issued a historic action making the first gene therapy available in the United States, ushering in a new approach to the treatment of cancer and other serious and life-threatening diseases.
The life-changing potential of gene therapy products is undeniable, but the cost, which could be 20 or 30 times the annual wages of the typical American, according to the director of the Center for Health Policy and Outcomes at the Memorial Sloan Kettering Cancer Center, will dramatically limit their reach.
草榴社区 is making its own contributions to gene and cell therapy through NovaCell, the Center for Cellular Engineering.
CURRENT RESEARCH
Sponsor: National Science Foundation Major Research Instrumentation grant
Start Date: 2020
Investigators: Dr. Gang Feng (PI); Dr. Jens Karlsson (supporting)
Description: The confocal Raman microscope with sophisticated environmental control will enable in vivo chemical mapping under a wide temperature range and different gas/liquid environments, providing high resolution and real-time structural and chemical fingerprints of materials and chemicals. More.
Sponsor: National Science Foundation Major Research Instrumentation grant
Start Date: 2020
Investigators: Dr. Anthony Lagalante (PI); Dr. Jacob Elmer (Co-PI); Dr. Aimee Eggler (Co-PI)
Description: Mass spectrometry is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. For NovaCell researchers, the instrumentation may be used for understanding the process of protein degradation and identifying molecular determinants of the proteasome's ability to unfold proteins, and for elucidating host cell response to gene therapy and improving transgene expression by inhibiting or circumventing host cell defenses. More
Sponsor: 草榴社区 CGT Consortium Project
Investigators: Eggler A., Bamezai, A. and Kelly, W.
Sponsor: GlaxoSmithKline
Start Date: 2019
Investigator: Dr. Jens Karlsson
Description: Research focusing on assessment and prevention of intracellular ice formation during cryopreservation, incorporating the use of 草榴社区鈥檚 unique high-speed imaging cryomicroscopy facility to detect the ultra-rapid intracellular freezing events. More
Sponsor: subaward
Start Date: 2019
Investigators: Redbud Labs, Inc. with Dr. William Kelly
Description: Focus on improving the bioreactors used to provide controlled delivery of nutrients and biomimetic stimuli in order to influence T-cell growth. More
Sponsor:
Start Date: 2019
Investigators: Dr. William Kelly (PI) with Dr. Zuyi 鈥淛acky鈥� Huang (co-PI) and Redbud Labs, Inc.
Description: Cell growth rate is a limiting factor in CAR-T therapy research. This grant will support the optimum configuration of Redbud鈥檚 bioreactor technology, testing T cells under a variety of conditions and different mediums, and developing a mathematical model that can predict cell growth rate based on conditions. More
Sponsor: National Science Foundation, CAREER grant
State Date: 2017
Investigator: Dr. Jacob Elmer
Description: The goal of this project is to improve gene therapy by identifying and modifying the genes involved in the immune response to extraneous DNA in several cancer cell lines. Such an approach is expected to enhance gene delivery by inhibiting the target genes with both small molecule inhibitors and inhibitor proteins. More
NOVACELL NEWS
The Department of Chemical and Biological Engineering within 草榴社区鈥檚 College of Engineering was proud to host the inaugural annual meeting of the Greater Philadelphia chapter of the Chinese Biopharmaceutical Association, USA (CBA).
NovaCell Researchers Well-Represented at Professional Conferences
NovaCell faculty and graduate students have been busy in 2023 participating in a variety of professional conferences.
William J. Kelly, PhD, joined 草榴社区 alum Dr. Kevin Curran 鈥�00 CLAS (Memorial Sloan Kettering Cancer Center - MSC) at the International Society for Cell and Gene Therapy (ISCT) in June 2023 in Paris, France. Dr. Kelly presented his work on a novel approach for selecting out the best subpopulations of CART cells for immunotherapy applications. Dr. Curran is a member of the NovaCell Advisory Board.